
It's 3 a.m. Your continuous glucose monitor (CGM) starts beeping: LOW. Your heart races. You stumble to the kitchen and gulp down a glass of orange juice.
But what if your sugar was never low at all?
This happens more often than you might think. Here's what every person with diabetes should know.
Why this matters to you
Hypoglycemia means low blood sugar: a reading below 70 mg/dL.
- Below 70: your body starts sounding the alarm.
- Below 40: this is dangerous. It can lead to seizures, coma, severe brain damage, and even death.
Low blood sugar is common in people with diabetes, especially those taking certain medicines. Knowing how to spot it, confirm it, and treat it can protect your brain and your life.
What does low blood sugar feel like?
Everyone is different. You may notice:
- Dizziness
- Sweating
- Confusion
- Feeling agitated, angry, or irritable
- Seizures, in severe cases
Repeated low sugars can also cause memory problems over time, which may contribute to cognitive impairment and dementia. That's why lows should never be ignored.
What to do: confirm first, then treat
Step 1: Confirm with a finger stick. Whenever you suspect a low, check your blood sugar with a finger-stick glucose meter. This is the most reliable way to know what's really happening.
Step 2: If it's truly low, treat it. Good options include:
- Orange juice
- Regular soda (not diet)
- Half a sandwich
- Peanut butter and jelly sandwich
- Glucose tablets: best when you need a quick recovery
Tip: Glucose tablets work fast, but your sugar can crash again afterward. Follow them with something more filling, like half a sandwich, to keep your sugar steady.
Can't check? If you have no way to test and you feel symptoms, don't wait. Treat it.
A real story from our clinic
One of our patients, an IT professional at a large tech company, has had diabetes for a few years. He has been seeing us for about five months.
When he started with us, we asked his insurance to cover a continuous glucose monitor. Seeing his sugar in real time helped him understand how food affected him. His A1C improved to 5.9 without adding any new medicines.
His medicines are metformin and Mounjaro.
Then something puzzling showed up. His CGM report showed low sugars while he was sleeping.
- One night, the alarm went off and he drank orange juice without checking a finger stick first.
- Another night, he woke up with a low reading, and it came back to normal on its own.
Here's the key clue: neither metformin nor Mounjaro causes low blood sugar on its own. So what was going on?
The "fake low": when your CGM is fooled
If you sleep on the side where your CGM sensor is, the pressure on the sensor can make it read falsely low. These are often called compression lows. They are not real low blood sugars.
In our patient's case, everything pointed to this:
- His lows happened only during sleep
- They fixed themselves without treatment
- He takes no medicines that cause lows
But don't ignore a low alarm just because it might be fake. Always confirm with a finger stick. Treat it only if the finger stick shows it's truly low.
Know your diabetes medicines
Medicines that CAN cause low blood sugar:
| Medicine type | Examples |
|---|---|
| Insulin (short- and long-acting) | All types of insulin |
| Sulfonylureas | Glimepiride |
| Meglitinides | Repaglinide (pushes the pancreas to make more insulin) |
Medicines that do NOT cause low blood sugar on their own:
| Medicine type | Examples |
|---|---|
| Biguanides | Metformin |
| Thiazolidinediones | Pioglitazone |
| SGLT2 inhibitors | Jardiance, Farxiga |
| GLP-1 / GIP medicines | Mounjaro |
Note: The medicines in the second table can still contribute to lows if you take them together with insulin or a sulfonylurea. Ask your doctor about your combination.
Could it be something else?
Most low blood sugar in people with diabetes comes from medicines. But a good doctor keeps an open mind and rules out other causes. For our patient, we considered:
- Insulinoma, a tumor that makes too much insulin. It is very rare (about 1 in a million). He never had lows with physical activity, so it was unlikely.
- Liver problems, which can cause lows. He has none.
- Adrenal insufficiency, a hormone problem that can cause lows. He doesn't have it.
With these ruled out, the most likely explanation was a false low from sensor pressure.
Myths vs. facts
| Myth | Fact |
|---|---|
| "My CGM is always right." | Pressure on the sensor during sleep can cause false lows. |
| "All diabetes pills cause low sugar." | Metformin, Jardiance, Farxiga, and Mounjaro don't cause lows on their own. |
| "Glucose tablets fix everything." | They work fast, but follow them with food to prevent another crash. |
| "A low alarm at night can be ignored." | Always confirm with a finger stick first. |
Quick recap
- Low sugar = below 70. Below 40 is an emergency.
- CGM says low? Confirm with a finger stick, especially at night.
- Treat only true lows, and follow fast sugar with real food.
Know someone who wears a CGM? Share this with them. It might save them a 3 a.m. glass of juice they never needed.
This article is for general education and is not a substitute for personal medical advice. Talk to your doctor about your own blood sugar and medicines.
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Book an appointment
Choose a time online with Dr. Vijay Katari, MD at our Frisco or McKinney office, or call (214) 884-2774.